非诺特罗
-_and_(SS)-_fenoterol.svg) | |
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| 臨床資料 | |
|---|---|
| AHFS/Drugs.com | Micromedex详细消费者药物信息 |
| 给药途径 | Inhalation (MDI) |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 |
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| 藥物動力學數據 | |
| 生物半衰期 | 6.5小時左右 [1][2][3][4] |
| 识别信息 | |
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| CAS号 | 13392-18-2  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.205.960 |
| 化学信息 | |
| 化学式 | C17H21NO4 |
| 摩尔质量 | 303.35 g/mol |
| 3D模型（JSmol） | |
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非诺特罗（Fenoterol） 是一種用來擴張呼吸道的β2肾上腺素受体激动药。非诺特罗 屬於拟交感神经药 β2 刺激劑和氣喘藥。
非诺特罗 由勃林格殷格翰製造和銷售，商品名稱為：Berotec N （備勞喘）。製造商有時也會把非诺特罗與ipratropium混和後銷售，商品名稱為 Berodual N （備喘全）。
醫學用途
[编辑]非诺特罗 是短效的 β2刺激劑。當非诺特罗使用超過建議的醫療用劑量（每日最多只能吸入八劑、每劑量需間隔至少五分鐘，若氣喘狀況沒好轉，則再吸入第二劑[5]）時，也會成為β1 受體刺激劑。
使用者可以於運動前吸入一劑，預防稍後因運動所誘發的氣喘（氣管痙攣）。[6]
副作用
[编辑]已知曾有患者在急性氣喘發作時吸入了高達80劑的非诺特罗，最終因而死亡。當患者發現非诺特罗已經無法緩解氣喘時，應當停止吸入非诺特罗，並盡快就醫。[7][8]
參見
[编辑]文獻來源
[编辑]- ^ Fenoterol Hydrobromide Drug Information, Professional. Drugs.com. 1996-01-01 [2018-06-11]. （原始内容存档于2019-08-25）.
- ^ Fenoterol - Drug Monograph. DrugInfoSys.com. 2016-10-27 [2018-06-11]. （原始内容存档于2020-11-27）.
- ^ Berotec Inhalation Solution (Fenoterol HBr). RxMed.com. [2018-06-11]. （原始内容存档于2021-04-20）.
- ^ Svedmyr, Nils. Fenoterol: A Beta2-adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy (Wiley). 1985-05-06, 5 (3): 109–126. ISSN 0277-0008. doi:10.1002/j.1875-9114.1985.tb03409.x.
- ^ Berotec N/Concise Prescribing Info/Full Prescribing info. 2018-02-28 [2018-02-28]. （原始内容存档于2020-11-23）.
Dosage / Direction for Use：
Acute Asthma Episodes: 1 puff is sufficient for prompt symptom relief in most cases, if breathing has not noticeably improved after 5 minutes, a second dose may be taken, up to a maximum of 8 puffs per day. If an attack has not been relieved by 2 puffs, further puffs may be required. In this situation, patients should consult the doctor or the nearest hospital immediately. (See Precautions).
Prophylaxis of Exercise Induced Asthma: 1-2 puffs prior to exercise, up to a maximum of 8 puffs per day.
Bronchial Asthma and Other Conditions with Reversible Airways Narrowing: If repeated dosing is required, 1-2 puffs for each administration, up to a maximum of 8 puffs per day. - ^ Management of acute exacerbations of asthma in adults. UpToDate. [2018-06-25]. （原始内容存档于2018-06-25）.
- ^ Beasley R, Pearce N, Crane J, Burgess C. Withdrawal of 非诺特罗 and the end of the New Zealand asthma mortality epidemic. International Archives of Allergy and Immunology. 1995, 107 (1-3): 325–7. PMID 7613161. doi:10.1159/000237016.
- ^ Spitzer WO, Suissa S, Ernst P, et al. The use of beta-agonists and the risk of death and near death from asthma. The New England Journal of Medicine. February 1992, 326 (8): 501–6. PMID 1346340. doi:10.1056/NEJM199202203260801.