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兰尼单抗

维基百科,自由的百科全书
兰尼单抗
单克隆抗体
种类Fab片段英语Fab fragment
目標血管内皮生长因子A英语Vascular endothelial growth factor A(VEGF-A)
臨床資料
商品名英语Drug nomenclatureLucentis, others
生物相似藥Ranibizumab-nuna,[1] Ranibizumab-eqrn,[2] Byooviz,[1][3] Cimerli,[2] Ranivisio,[4] Susvimo,[5] Ximluci[6]
AHFS/Drugs.comMonograph
MedlinePlusa607044
核准狀況
懷孕分級
给药途径静脉注射
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物半衰期约9天[10]
识别信息
CAS号347396-82-1  checkY
DrugBank
ChemSpider
  • none
UNII
KEGG
ChEMBL
化学信息
化学式C2158H3282N562O681S12
摩尔质量48,379.97 g·mol−1

兰尼单抗(英語:Ranibizumab,也译为雷珠单抗,商品名Lucentis)是一种单克隆抗体片段(FAB),其与贝伐单抗(bevacizumab)是从相同亲本鼠抗体获得。它比母体分子小得多,能更紧密的结合到血管内皮生长因子-A(VEGF-A)。它是一种血管生成抑制剂(angiogenesis inhibitor),已被批准用于治疗的“湿”型老年黄斑变性

参考资料

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  1. ^ 1.0 1.1 1.2 Byooviz Nuna- ranibizumab injection, solution. DailyMed. 2022-04-27 [2022-08-02]. (原始内容存档于2022-08-03). 
  2. ^ 2.0 2.1 2.2 Cimerli- ranibizumab-eqrn injection, solution. DailyMed. 2022-10-19 [2023-01-21]. (原始内容存档于2023-01-21). 
  3. ^ 3.0 3.1 Byooviz EPAR. European Medicines Agency. 2021-06-23 [2021-09-09]. (原始内容存档于2021-09-10).  Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  4. ^ 4.0 4.1 Ranivisio EPAR. European Medicines Agency (EMA). 2022-06-20 [2022-10-06]. (原始内容存档于2022-10-06).  Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  5. ^ 5.0 5.1 Susvimo- ranibizumab injection, solution. DailyMed. [2021-12-19]. (原始内容存档于2021-12-19). 
  6. ^ 6.0 6.1 Ximluci EPAR. European Medicines Agency. 2022-09-14 [2023-03-03]. (原始内容存档于2023-03-13).  Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  7. ^ 7.0 7.1 AusPAR: Ranibizumab. Therapeutic Goods Administration (TGA). 2014-12-09 [2021-09-20]. (原始内容存档于2021-09-21). 
  8. ^ 8.0 8.1 https://www.tga.gov.au/resources/auspmd/byooviz [裸露网址]
  9. ^ Summary Basis of Decision - Byooviz. Health Canada. 2022-08-12 [2022-09-29]. (原始内容存档于2022-09-29). 
  10. ^ 10.0 10.1 Lucentis- ranibizumab injection, solution. DailyMed. [2021-09-20]. (原始内容存档于2021-09-21). 
  11. ^ Lucentis EPAR. European Medicines Agency. 2018-09-17 [2021-09-09]. (原始内容存档于2021-09-10).  Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

外部链接

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