敌百虫

敌百虫
臨床資料
商品名（英语：Drug nomenclature）	Chlorophos (and many others)Trichlorfon; Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl) dimethylphosphonate; Agroforotox; Anthon; Chlorofos; Chloroftalm; Chlorophos; Chlorophthalm; Chloroxyphos; Combot; Dimethyl (trichlorohydroxyethyl)phosphonate; Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; Dipterax; Dipterex; Dipterex 50; Diptevur; Ditrifon; Dylox; Dyrex; Dyvon; DEP; DEP (Pesticide); DETF; ENT 19,763; Flibol E; Fliegenteller; Forotox; Foschlor; Foschlor R; Foschlor R 50; Hypodermacid; Loisol; Masoten; Mazoten; Methyl Chlorophos; Metifonate; Metriphonate; Neguron; Neguvon; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; O,O-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; O,O-Dimethyl (2,2,2-trichlorohydroxyethyl)phosphonate; Phoschlor; Phoschlor R50; Polfoschlor; Ricifon; Ritsifon; Soldep; Sotipox; Trichlorphon; Trichlorphon FN; Tugon; Volfartol; Votexit; Wotexit; WEC 50; (1-Hydroxy-2,2,2-trichloroethyl)phosphonic acid, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl)phosphonate, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl)phosphonic acid dimethyl ester; Bayer L 1359; Bilarcil; Bovinox; Briton; BAY 15922; Cekufon; Chlorophosciclosom; Clorofos; Danex; Dimethoxy-(2,2,2-trichloro-1-hydroxyethyl)phosphine oxide; Equino-Aid; Foschlorem; Khloroftalm; NCI-C54831; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphate; O,O-Dimethyl-(1-hydroxy-2,2,2-trichloraethyl)phosphosaeure ester; O,O-Dimethyl-(1-hydroxy-2,2,2-trichlorathyl)-phosphat; O,O-Dimethyl-(2,2,2-trichloor-1-hydroxy-ethyl)-fosfonaat; O,O-Dimethyl-(2,2,2-trichlor-1-hydroxy-aethyl)phosphonat; O,O-Dimetil-(2,2,2-tricloro-1-idrossi-etil)-fosfonato; Phosphonic acid, (1-hydroxy-2,2,2-trichloroethyl)-, dimethyl ester; Proxol; Trichloorfon; Trichlorofon; Trichlorophon; Trinex; 1-Hydroxy-2,2,2-trichloro-ethyle phosphonate de dimethyle; Bay-L 1359; Briten; Denkaphon; Dipterex WP 80; Ertefon; OMS 800; Zeltivar; Onefon; O,O-Dimethyl-1-oxy-2,2,2-trichloroethyl phosphonate;Trichlorfon; 1-Hydroxy-2,2,2-trichloroethylphosphonate-O,O-dimethyl ester; Phosphonic acid, P-(2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; Chlorak; Dimetox; Dioxaphos
其他名稱	Trichlorphon
AHFS/Drugs.com	国际药品名称
ATC碼	P02BB01 (WHO) QP52AB01 QP53AF02;
藥物動力學數據
生物半衰期	3 hours
识别信息
	IUPAC命名法 (RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; ;
CAS号	52-68-6
PubChem CID	5853;
ChemSpider	5644 ;
UNII	DBF2DG4G2K;
KEGG	C07971 ;
ChEBI	CHEBI:6908 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID0021389 ;
ECHA InfoCard	100.000.137
化学信息
化学式	C4H8Cl3O4P
摩尔质量	257.436 g/mol
3D模型（JSmol（英语：JSmol））	交互式图像;
手性	Racemic mixture
	SMILES COP(=O)(C(C(Cl)(Cl)Cl)O)OC;
	InChI InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3 ; Key:NFACJZMKEDPNKN-UHFFFAOYSA-N ;

敌百虫（英語：trichlorfon，也称为美曲磷酯，Metrifonate）是一种有机磷酸酯杀虫剂和乙酰胆碱酯酶抑制剂（英语：acetylcholinesterase inhibitor）^[3]，是一种前体药物，可在非酶促情况下转化为敌敌畏，可用于治疗血吸虫病^[4]，但没有商业化应用^[5]，也有提议用于治疗阿茲海默症，但并未通过^[6]。

参考文献

^ Trichlorfon. Haz-Map. U.S. National Library of Medicine. August 2015 [2015-10-13]. （原始内容存档于2015-09-20）.
^ Metrifonate. U.S. National Institute of Standards and Technology. [2016-09-04]. （原始内容存档于2020-04-03）.
^ NLH - Neurological Conditions - Metrifonate for Alzheimer's disease. （原始内容存档于2009-07-19）.
^ Monographs: Pharmaceutical substances: Metrifonate (Metrifonatum). The International Pharmacopoeia Fourth Edition. WHO. [2015-10-20]. （原始内容存档于2016-06-03）. (dead link 31 January 2019)
^ Ross AG, Bartley PB, Sleigh AC, Olds GR, Li Y, Williams GM, McManus DP. Schistosomiasis. The New England Journal of Medicine. April 2002, 346 (16): 1212–20. PMID 11961151. doi:10.1056/NEJMra012396.
^ López-Arrieta JM, Schneider L. López-Arrieta J , 编. Metrifonate for Alzheimer's disease. The Cochrane Database of Systematic Reviews. April 2006, (2): CD003155. PMID 16625573. doi:10.1002/14651858.CD003155.pub3.

这是一篇关于有机化合物的小作品。您可以通过编辑或修订扩充其内容。

[1] Trichlorfon. Haz-Map. U.S. National Library of Medicine. August 2015 [2015-10-13]. （原始内容存档于2015-09-20）.

[2] Metrifonate. U.S. National Institute of Standards and Technology. [2016-09-04]. （原始内容存档于2020-04-03）.

[urlNLH_-_Neurological_Conditions_-_Metrifonate_for_Alzheimers_disease-3] NLH - Neurological Conditions - Metrifonate for Alzheimer's disease. （原始内容存档于2009-07-19）.

[4] Monographs: Pharmaceutical substances: Metrifonate (Metrifonatum). The International Pharmacopoeia Fourth Edition. WHO. [2015-10-20]. （原始内容存档于2016-06-03）. (dead link 31 January 2019)

[urlschistosomiasis-5] Ross AG, Bartley PB, Sleigh AC, Olds GR, Li Y, Williams GM, McManus DP. Schistosomiasis. The New England Journal of Medicine. April 2002, 346 (16): 1212–20. PMID 11961151. doi:10.1056/NEJMra012396.

[6] López-Arrieta JM, Schneider L. López-Arrieta J , 编. Metrifonate for Alzheimer's disease. The Cochrane Database of Systematic Reviews. April 2006, (2): CD003155. PMID 16625573. doi:10.1002/14651858.CD003155.pub3.

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