黑板树碱

黑板树碱
识别
CAS号	123045-72-7
PubChem	11969856
ChemSpider	10258956
SMILES	C/C=C\1/C=[N+]([C@H]2C[C@@H]1C([C@@]34[C@@]2(Nc5c3cccc5)O[C@H](C4)OC)C(=O)OC)[O-];
性质
化学式	C21H24N2O5
摩尔质量	384.43 g·mol−1
密度	1.339 g/cm3
熔点	233-240 °C（分解）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

黑板树碱是一种吲哚生物碱（英语：Indole alkaloid），化学式为C₂₁H₂₄N₂O₅。它最初于1989年从黑板树（Alstonia scholaris）的树叶中发现，^[1]^[2]^[3]在有机溶剂提取后，通过柱分离法进行提纯。^[1]它可以和COA6（英语：COA6）蛋白强烈结合。^[4]

参考文献

^ ^1.0 ^1.1 ^1.2 ^1.3 ABE, Fumiko; CHEN, Rong-Fu; YAMAUCHI, Tatsuo; MARUBAYASHI, Nobuhiro; UEDA, Ikuhiko. Alschomine and isoalschomine, new alkaloids from the leaves of Alstonia scholaris.. Chemical & Pharmaceutical Bulletin. 1989, 37 (4): 887–890. ISSN 0009-2363. doi:10.1248/cpb.37.887 .
^ Yamauchi, Tatsuo; Abe, Fumiko; Chen, Rong-fu; Nonaka, Gen-Ichiro; Santisuk, Thawatchai; Padolina, William G. Alkaloids from the leaves of Alstonia scholaris in Taiwan, Thailand, Indonesia and the Philippines. Phytochemistry. 1990, 29 (11): 3547–3552. Bibcode:1990PChem..29.3547Y. ISSN 0031-9422. doi:10.1016/0031-9422(90)85273-I.
^ Mammen Daniel. Medicinal Plants: Chemistry and Properties. Science Publishers. 2006: 24– [25 August 2013]. ISBN 978-1-57808-395-4.
^ Hong Luo; Zhiyong Wang. Pan-cancer analysis reveals potential immunological and prognostic roles of COA6 in human cancers and preliminary exploration of COA6 in bladder cancer. Cellular Signalling, 2024. 117. 111111. doi:10.1016/j.cellsig.2024.111111.

[ABECHEN1989-1] 1.0 ^1.1 ^1.2 ^1.3 ABE, Fumiko; CHEN, Rong-Fu; YAMAUCHI, Tatsuo; MARUBAYASHI, Nobuhiro; UEDA, Ikuhiko. Alschomine and isoalschomine, new alkaloids from the leaves of Alstonia scholaris.. Chemical & Pharmaceutical Bulletin. 1989, 37 (4): 887–890. ISSN 0009-2363. doi:10.1248/cpb.37.887 .

[YamauchiAbe1990-2] Yamauchi, Tatsuo; Abe, Fumiko; Chen, Rong-fu; Nonaka, Gen-Ichiro; Santisuk, Thawatchai; Padolina, William G. Alkaloids from the leaves of Alstonia scholaris in Taiwan, Thailand, Indonesia and the Philippines. Phytochemistry. 1990, 29 (11): 3547–3552. Bibcode:1990PChem..29.3547Y. ISSN 0031-9422. doi:10.1016/0031-9422(90)85273-I.

[Daniel2006-3] Mammen Daniel. Medicinal Plants: Chemistry and Properties. Science Publishers. 2006: 24– [25 August 2013]. ISBN 978-1-57808-395-4.

[4] Hong Luo; Zhiyong Wang. Pan-cancer analysis reveals potential immunological and prognostic roles of COA6 in human cancers and preliminary exploration of COA6 in bladder cancer. Cellular Signalling, 2024. 117. 111111. doi:10.1016/j.cellsig.2024.111111.

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