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K252b

维基百科,自由的百科全书
(重定向自C26H19N3O5
K252b
IUPAC名
(15S,16R,18R)-16-Hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylic acid
识别
CAS号 99570-78-2
PubChem 3814
9981344
9846716
ChemSpider 8156936
SMILES
 
  • C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
InChI
 
  • InChI=1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1
InChIKey AMSOPBXQXSAAAC-PLZPTFKGSA-N
ChEBI 208814
性质
化学式 C26H19N3O5
摩尔质量 453.45 g·mol−1
外观 White to light yellow powder
溶解性 可溶于DMSO甲醇
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

K252b是一种吲哚咔唑生物碱,分子式C26H19N3O5,结构上与星形孢菌素K252a类似[1],1986年在细菌中发现。在体外实验中可作为蛋白激酶抑制剂,消除神经生长因子PC12细胞周围神经系统神经元的影响[2]

参考文献

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  1. ^ Nakano, Hirofumi; Ōmura, Satoshi. Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine. The Journal of Antibiotics. January 2009, 62 (1): 17–26. ISSN 1881-1469. PMID 19132059. doi:10.1038/ja.2008.4 (英语). 
  2. ^ Cheng, Bin; Barger, Steven W.; Mattson, Mark P. Staurosporine, K-252a, and K-252b Stabilize Calcium Homeostasis and Promote Survival of CNS Neurons in the Absence of Glucose. Journal of Neurochemistry. April 1994, 62 (4): 1319–1329. ISSN 0022-3042. PMID 7510777. S2CID 19294051. doi:10.1046/j.1471-4159.1994.62041319.x (英语). 

外部連結

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