蛛毒素受體2
外觀
蛛毒素受體2(英語:Latrophilin 2)是一種在人類中由ADGRL2基因編碼的蛋白質。[5][6]
該基因編碼G蛋白偶聯受體(GPCR)的蛛毒素受體亞家族成員。蛛毒素受體可能在細胞黏附和信號轉導中發揮作用。在非人類物種的實驗中,富含半胱氨酸的GPS(G蛋白偶聯受體蛋白水解位點)結構域內的內源性蛋白水解切割產生兩個亞基(一個大的細胞外N末端細胞黏附亞基和一個與GPCR的促胰液素/降鈣素家族具有實質相似性的亞基)非共價結合在細胞膜上。雖然已經描述了幾種轉錄變體,但僅確定了其中一種的生物學有效性。[6]
參見
[編輯]參考資料
[編輯]- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ White GR, Varley JM, Heighway J. Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. Apr 2000, 1491 (1–3): 75–92. PMID 10760572. doi:10.1016/s0167-4781(00)00020-8.
- ^ 6.0 6.1 Entrez Gene: LPHN2 latrophilin 2.
延申閱讀
[編輯]- Südhof TC. alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. Annual Review of Neuroscience. 2001, 24 (1): 933–62. PMID 11520923. doi:10.1146/annurev.neuro.24.1.933.
- Ushkaryov YA, Volynski KE, Ashton AC. The multiple actions of black widow spider toxins and their selective use in neurosecretion studies. Toxicon. Apr 2004, 43 (5): 527–42. PMID 15066411. doi:10.1016/j.toxicon.2004.02.008.
- Bonaldo MF, Lennon G, Soares MB. Normalization and subtraction: two approaches to facilitate gene discovery. Genome Research. Sep 1996, 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791 .
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Research. Oct 1998, 5 (5): 277–86. PMID 9872452. doi:10.1093/dnares/5.5.277 .
- White GR, Varley JM, Heighway J. Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. Oncogene. Dec 1998, 17 (26): 3513–9. PMID 10030676. doi:10.1038/sj.onc.1202487 .
- Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. The Journal of Biological Chemistry. Oct 2000, 275 (42): 32387–90. PMID 10964907. doi:10.1074/jbc.C000490200 .
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics. Jul 2004, 84 (1): 23–33. PMID 15203201. doi:10.1016/j.ygeno.2003.12.004.
- Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE. Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biology. 2007, 8 (4): R64. PMC 1896007 . PMID 17456239. doi:10.1186/gb-2007-8-4-r64.