阿维扎封
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| 临床资料 | |
|---|---|
| 给药途径 | 肌肉注射 |
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| 识别信息 | |
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| CAS号 | 65617-86-9  |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C22H27ClN4O3 |
| 摩尔质量 | 430.93 g·mol−1 |
| 3D模型（JSmol） | |
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阿维扎封（英语：Avizafone[1]或Pro-Diazepam）是苯二氮䓬衍生物地西泮的水溶性前药。它可以用于肌肉内给药。
阿维扎封被血液中的酶代谢形成活性药物地西泮。主要用作有机磷类神经毒剂中毒的解毒剂。[2][3][4]
参见
[编辑]参考资料
[编辑]- ^ GB 1517164
- ^ Karlsson B, Lindgren B, Millquist E, Sandberg M, Sellström A. On the use of diazepam and pro-diazepam (2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig. The Journal of Pharmacy and Pharmacology. April 1990, 42 (4): 247–51. PMID 1974291. S2CID 32369013. doi:10.1111/j.2042-7158.1990.tb05401.x.
- ^ Lallement G, Renault F, Baubichon D, Peoc'h M, Burckhart MF, Galonnier M, et al. Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics. Archives of Toxicology. October 2000, 74 (8): 480–6. PMID 11097386. S2CID 22292597. doi:10.1007/s002040000146.
- ^ Taysse L, Calvet JH, Buée J, Christin D, Delamanche S, Breton P. Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose. Toxicology. June 2003, 188 (2–3): 197–209. PMID 12767691. doi:10.1016/s0300-483x(03)00086-6.