HPTE

HPTE
	IUPAC名; 4,4'-(2,2,2-Trichloro-1,1-ethanediyl)diphenol
別名	p,p'-Hydroxy-DDT; Hydroxychlor; 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane; 1,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethane
識別
CAS號	2971-36-0
PubChem	76302
ChemSpider	68781
SMILES	C1=CC(=CC=C1C(C2=CC=C(C=C2)O)C(Cl)(Cl)Cl)O;
InChI	1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H;
InChIKey	IUGDILGOLSSKNE-UHFFFAOYSA-N
Beilstein	2054671
EINECS	623-854-1
ChEBI	34025
KEGG	C14136
性質
化學式	C14H11Cl3O2
摩爾質量	317.59 g·mol−1
危險性
	GHS危險性符號;
GHS提示詞	Warning
H-術語	H315, H319, H335
P-術語	P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

HPTE或2,2-雙(4-羥苯基)-1,1,1-三氯乙烷（英語：2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane）是有機氯殺蟲劑甲氧滴滴涕在人體中的初級代謝產物^[1]。HPTE和雙酚A等結構上類似，是一種內分泌干擾素，帶有雌激素活性^[2]，可干擾孕酮生成^[3]並抑制3α-羥基類固醇脫氫酶活性^[4]。

參考文獻

^ Leung-Gurung, Lucie; Escalante Cobb, Priscilla; Mourad, Faraj; Zambrano, Cristina; Muscato, Zachary; Sanchez, Victoria; Godde, Kanya; Broussard, Christine. Methoxychlor metabolite HPTE alters viability and differentiation of embryonic thymocytes from C57BL/6 mice. Journal of Immunotoxicology. 4 July 2018, 15 (1): 104–118. doi:10.1080/1547691X.2018.1474978.
^ Hewitt, Sylvia C.; Korach, Kenneth S. Estrogenic Activity of Bisphenol A and 2,2-bis( -Hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles. Environmental Health Perspectives. January 2011, 119 (1): 63–70. doi:10.1289/EHP.1002347.
^ Akgul, Yucel; Derk, Raymond C.; Meighan, Terence; Rao, K. Murali Krishna; Murono, Eisuke P. The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production. Reproductive Toxicology. July 2011, 32 (1): 77–84. doi:10.1016/J.REPROTOX.2011.05.013.
^ Mao, Baiping; Wu, Chengyun; Zheng, Wenwen; Shen, Qiuxia; Wang, Yiyan; Wang, Qiufan; Lin, Han; Li, Xiaoheng; Sun, Jianliang; Ge, Ren-Shan. Methoxychlor and its metabolite HPTE inhibit rat neurosteroidogenic 3α-hydroxysteroid dehydrogenase and retinol dehydrogenase 2. Neuroscience Letters. 2018-09, 684: 169–174. doi:10.1016/j.neulet.2018.08.008.

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