SRY基因(sex-determining region of Y-chromosome,全稱:Y染色體性別決定區),又名睪丸決定因子,(英語:Testis-determining factor,簡稱TDF)是人體Y染色體上的一段基因片段,該基因是決定男性睾丸發育的主要基因。存在於Y染色體的短臂末端上。
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