双环铂
 双环铂的化学结构 | |
| 临床资料 | |
|---|---|
| 商品名 | Dicycloplatin |
| 其他名称 | Platinum(2+) 1-carboxycyclobutanecarboxylate ammoniate (1:2:2), 1,1-Cyclobutanedicarboxylic acid, compd. with (sp-4-2)-diammine(1,1-cyclobutanedi(carboxylato-kappaO)(2-))platinum (1:1) |
| 给药途径 | Intravenous |
| 药物动力学数据 | |
| 生物利用度 | 100% (IV) |
| 血浆蛋白结合率 | < 88.7% |
| 生物半衰期 | 24.49 - 108.93 hours |
| 排泄途径 | Renal |
| 识别信息 | |
| |
| CAS号 | 287402-09-9  |
| ChemSpider | |
| UNII | |
| 化学信息 | |
| 化学式 | C12H20N2O8Pt |
| 摩尔质量 | 515.382 g/mol |
| 3D模型（JSmol） | |
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双环铂是一种化疗药物，用于治疗包括非小细胞肺癌和前列腺癌在内的多种癌症。[1]
双环铂治疗过程中观察到的副作用包括恶心、呕吐、血小板减少、嗜中性白血球低下、贫血、疲劳、厌食、肝酶升高和脱发等。这些药物是铂基抗肿瘤药物的一种，它的作用方式是使线粒体功能障碍，导致细胞死亡。[2].
参考文献
[编辑]- ^ D., Zhao; Y., Zhang; C., Xu; C., Dong; H., Lin; L., Zhang; C., Li; S., Ren; X., Wang; S., Yang; D., Han; X., Chen. Pharmacokinetics, Tissue Distribution, and Plasma Protein Binding Study of Platinum Originating from Dicycloplatin, a Novel Antitumor Supramolecule, in Rats and Dogs by ICP-MS. Biological Trace Element Research. February 2012, 148: 203–208. doi:10.1007/s12011-012-9364-2.
- ^ G.Q., Li; X.G., Chen; X.P., Wu; J.D., Xie; Y.J., Liang; X.Q., Zhao; W.Q, Chen; L.W., Fu. Effect of Dicycloplatin, a Novel Platinum Chemotherapeutical Drug, on Inhibiting Cell Growth and Inducing Cell Apoptosis. PLOS ONE. November 2012, 7 (11). doi:10.1371/journal.pone.0048994.